mRNA-Based Anti-TCR CDR3 Tumour Vaccine for T-Cell Lymphoma

نویسندگان

چکیده

Efficient vaccination can be achieved by injections of in vitro transcribed mRNA (ivt mRNA) coding for antigens. This vaccine format is particularly versatile and allows the production individualised vaccines conferring, T-cell immunity against specific cancer mutations. The CDR3 hypervariable regions immune receptors (T-cell receptor, TCR or B-cell BCR) context T- leukaemia lymphoma are targetable sequences, similar to We evaluated functionality an mRNA-based designed trigger EL4 T-lymphoma cell line-derived murine vivo model. Vaccination proved a feasible approach allowed protection T-lymphoma, even though escape terms downregulation paralleled therapeutic effect. However, analysis human cutaneous samples indicated that, as case B-lymphomas, clonotypic receptor may driver mutation not downregulated upon treatment. Thus, using customised ivt promising immunotherapy method explored treatment patients with lymphomas.

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ژورنال

عنوان ژورنال: Pharmaceutics

سال: 2021

ISSN: ['1999-4923']

DOI: https://doi.org/10.3390/pharmaceutics13071040