mRNA-Based Anti-TCR CDR3 Tumour Vaccine for T-Cell Lymphoma
نویسندگان
چکیده
Efficient vaccination can be achieved by injections of in vitro transcribed mRNA (ivt mRNA) coding for antigens. This vaccine format is particularly versatile and allows the production individualised vaccines conferring, T-cell immunity against specific cancer mutations. The CDR3 hypervariable regions immune receptors (T-cell receptor, TCR or B-cell BCR) context T- leukaemia lymphoma are targetable sequences, similar to We evaluated functionality an mRNA-based designed trigger EL4 T-lymphoma cell line-derived murine vivo model. Vaccination proved a feasible approach allowed protection T-lymphoma, even though escape terms downregulation paralleled therapeutic effect. However, analysis human cutaneous samples indicated that, as case B-lymphomas, clonotypic receptor may driver mutation not downregulated upon treatment. Thus, using customised ivt promising immunotherapy method explored treatment patients with lymphomas.
منابع مشابه
Peripheral T-cell Lymphoma of the Uvula: A Rare Entity
Abstract Introduction: Extra-nodal exposition of T-cell non-hodgkin lymphoma (NHL) is extremely rare, and is frequently observed in patients with immune system dysfunction. Peripheral T-cell lymphoma does not express CD56 is rare. Malignant lymphoma of the uvula is exceedingly unusual. The current study reported a case of peripheral T-cell lymphoma of the uvula in an immunecompetent patient. ...
متن کاملHypocalcemia Revealing an Enteropathy-Associated T-cell Lymphoma
Background: Neurofollicular hamartoma (NFH) is characterized histopathologically by fascicles of spindle cells that laterally delimited by hyperplastic folliculosebaceous units. It usually appears on face, near the nose or nasolabial fold. It does not manifest true neural differentiation and recently the term spindle cell predominant trichodiscoma (SCPT) has been used instead. Case Presentatio...
متن کاملSpecific cutaneous manifestations in adult T cell leukemia/lymphoma
Background and aim: Adult T cell leukemia/lymphoma (ATLL) is an aggresive malignancy which may occur in human T lymphotropic virus1(HTLV1) infected persons. HTLV1 is endemic in Khorasan with prevalence of 2.3% in general population. Since specific cutaneous manifestations of lymphoma may occur in a significant number of patients, we studied ATLL patients in Mashhad.Mate...
متن کاملPeripheral T-cell Lymphoma of the Uvula: A Rare Entity
Abstract Introduction: Extra-nodal exposition of T-cell non-hodgkin lymphoma (NHL) is extremely rare, and is frequently observed in patients with immune system dysfunction. Peripheral T-cell lymphoma does not express CD56 is rare. Malignant lymphoma of the uvula is exceedingly unusual. The current study reported a case of peripheral T-cell lymphoma of the uvula in an immunecompetent patient. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2021
ISSN: ['1999-4923']
DOI: https://doi.org/10.3390/pharmaceutics13071040